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Michael O'Brien

School of MedicineEmail Michael O'Brien

Kevin O'Connor

School of Medicine

Dr. Kevin C. O’Connor is an Associate Professor of Neurology at Yale University. He earned a BS in Chemistry from the University of Massachusetts at Amherst and his Ph.D. in Biochemistry at Tufts Medical School. He took his post-doctoral training in Immunology at Harvard where he also spent several years as an Assistant Professor. His investigative interests are in human translational neuroimmunology, with specific focus on defining the mechanisms by which B-cells affect tissue damage in autoimmunity. To this end, his group is engaged in understanding how B-cell subsets initiate and sustain autoimmunity. His team’s accomplishments include refining the role of Epstein-Barr virus in the multiple sclerosis (MS) brain and further defining the role of autoantibodies in children and adults with MS. They recently identified a network of B-cells that populate the MS central nervous system by trafficking through the cervical lymph nodes. Their current efforts include defining the immunopathology of myasthenia gravis (MG). His group demonstrated that MG antigen-specific T-cells belong to the pro-inflammatory Th17 subset and determined that MG patients harbor defects in B-cell tolerance. Their current focus is on describing the mechanisms of autoantibody production in MG, using high-throughput sequencing, toward the aim of improving therapeutic approaches.

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Vanessa Ogle

History
I am a historian of global Europe from the 18th century to the present, focusing on the history of capitalism, economic history, and empire in global and comparative perspective. While my particular interests lie in Western Europe (Britain, France, Germany, mostly), I conceive of Europe broadly and seek to place European history in the context of its interactions with the wider world. The sprawling nature of capitalism and the world economy require an engagement with non-European history. Similarly, Europe’s imperial and colonial past beyond the geographic boundaries of the continent is an important part of that history. My first book, The Global Transformation of Time: 1870-1950, explored the history of globalization, tracing changing political, economic, and legal regimes of time during an area of intensified interactions between Europe and other world regions. The book follows time in its different manifestations as social and economic clock time and calendar time from Germany, France, and Britain, to British India, the colonial world broadly, the late Ottoman Levant and Egypt, and the League of Nations. I consider this book a reflection on how to conceptualize the movement of goods, people, and ideas in global and international perspective. I published an article related to the book in The American Historical Review in 2013.
 
I am currently completing a project titled Archipelago Capitalism: A History of the Offshore World, 1920s-1980s. The book reopens the history of twentieth-century political economy and capitialism (in its free-market, neoliberal variety in particular) in Europe and beyond, by pointing to an economic,  legal, and political regime of smaller, often enclave-like territories and spaces that thrived on the sidelines of a world otherwise increasingly dominated by nation-states: tax havens, offshore finance, flags of convenience, and free trade zones. At the same time, the book provides the first archivally-based account of how ‘offshore’ came into existence as a sophisticated, far-flung system often beyond the reach of national regulators and governments. The book thus seeks to shed light on the origins of tax avoidance and evasion on a global scale, one of the most pressing current problems with profound implications for the rise of inequality throughout the twentieth century. The project uses a multi-archival approach that combines documents from over 30 national archives, central banks, multilateral institutions, private banks, and oral history interviews in locations such as Australia, Bahamas, Britain, Canada, Cayman Islands, France, Germany, Guernsey, Ireland, Jersey, Luxembourg, Panama, Singapore, Switzerland, and the US. A pilot article based off this work was published in The American Historical Review in December 2017, another one in Past and Present in 2020.
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